Identification of novel non-toxic and anti-angiogenic α-fluorinated chalcones as potent colchicine binding site inhibitors

α-Fluorinated chalcones were prepared and evaluated for their cell growth inhibitory properties against six human cancer cell lines. The most potent chalcone 4c demonstrated excellent selective toxicity against cancer cells versus normal human cells, with IC(50) values at nanomolar concentration ran...

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Detalles Bibliográficos
Autores principales: Sun, Moran, Yuan, Minghua, Kang, Yingying, Qin, Jinling, Zhang, Yixin, Duan, Yongtao, Wang, Longfei, Yao, Yongfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741257/
https://www.ncbi.nlm.nih.gov/pubmed/34979843
http://dx.doi.org/10.1080/14756366.2021.2014831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741257/
https://www.ncbi.nlm.nih.gov/pubmed/34979843
http://dx.doi.org/10.1080/14756366.2021.2014831

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