Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats

The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However, targeting this channel directly has failed, and an indirect approach...

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Detalles Bibliográficos
Autores principales: Li, Jiahe, Stratton, Harrison J., Lorca, Sabina A., Grace, Peter M., Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741281/
https://www.ncbi.nlm.nih.gov/pubmed/34983286
http://dx.doi.org/10.1080/19336950.2021.2023383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741281/
https://www.ncbi.nlm.nih.gov/pubmed/34983286
http://dx.doi.org/10.1080/19336950.2021.2023383

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