Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cells

CTLA4-CD28 gene fusion has been reported to occur in diverse types of T cell lymphoma. The fusion event is expected to convert inhibitory signals to activating signals and promote proliferation and potentially transformation of T cells. To test the function of the CTLA4-CD28 fusion gene in vivo, we...

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Detalles Bibliográficos
Autores principales: Lee, Gyu Jin, Jun, Yukyung, Jeon, Yoon Kyung, Lee, Daekee, Lee, Sanghyuk, Kim, Jaesang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741289/
https://www.ncbi.nlm.nih.gov/pubmed/35003894
http://dx.doi.org/10.1080/2162402X.2021.2015170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741289/
https://www.ncbi.nlm.nih.gov/pubmed/35003894
http://dx.doi.org/10.1080/2162402X.2021.2015170

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