CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibition

NK group 2, member D (NKG2D) is one of the most critical activating receptors expressed by natural killer (NK) cells. There is growing evidence that acute myeloid leukemia (AML) cells may evade NK cell-mediated cell lysis by expressing low or no ligands for NKG2D (NKG2D-Ls). We hypothesized that CCA...

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Detalles Bibliográficos
Autores principales: Liu, Meng, Du, Mengbao, Yu, Jian, Qian, Zijun, Gao, Yang, Pan, Wenjue, Zhao, Xiujie, Wang, Mowang, Li, Huimin, Zheng, Jiaqi, Huang, Qianshuo, Wang, Li-Mengmeng, Xiao, Haowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741297/
https://www.ncbi.nlm.nih.gov/pubmed/35003895
http://dx.doi.org/10.1080/2162402X.2021.2016158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741297/
https://www.ncbi.nlm.nih.gov/pubmed/35003895
http://dx.doi.org/10.1080/2162402X.2021.2016158

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