Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation

Post-translationally modified tau is the primary component of tau neurofibrillary tangles, a pathological hallmark of Alzheimer's disease and other tauopathies. Post-translational modifications (PTMs) within the tau microtubule (MT)-binding domain (MBD), which encompasses two hexapeptide motifs...

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Detalles Bibliográficos
Autores principales: Acosta, Diana M., Mancinelli, Chiara, Bracken, Clay, Eliezer, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741514/
https://www.ncbi.nlm.nih.gov/pubmed/34838590
http://dx.doi.org/10.1016/j.jbc.2021.101442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741514/
https://www.ncbi.nlm.nih.gov/pubmed/34838590
http://dx.doi.org/10.1016/j.jbc.2021.101442

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