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Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation
Post-translationally modified tau is the primary component of tau neurofibrillary tangles, a pathological hallmark of Alzheimer's disease and other tauopathies. Post-translational modifications (PTMs) within the tau microtubule (MT)-binding domain (MBD), which encompasses two hexapeptide motifs...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741514/ https://www.ncbi.nlm.nih.gov/pubmed/34838590 http://dx.doi.org/10.1016/j.jbc.2021.101442 |