T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation

Adoptive transfer of T-cell-receptor (TCR)-transduced T cells has shown promising results for cancer treatment, but has also produced severe immunotoxicities caused by on-target as well as off-target TCR recognition. Off-target toxicities are related to the ability of a single T cell to cross-recogn...

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Detalles Bibliográficos
Autores principales: Bentzen, Amalie Kai, Hadrup, Sine Reker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741623/
https://www.ncbi.nlm.nih.gov/pubmed/35036898
http://dx.doi.org/10.1016/j.iotech.2019.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741623/
https://www.ncbi.nlm.nih.gov/pubmed/35036898
http://dx.doi.org/10.1016/j.iotech.2019.06.003

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