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T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation
Adoptive transfer of T-cell-receptor (TCR)-transduced T cells has shown promising results for cancer treatment, but has also produced severe immunotoxicities caused by on-target as well as off-target TCR recognition. Off-target toxicities are related to the ability of a single T cell to cross-recogn...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741623/ https://www.ncbi.nlm.nih.gov/pubmed/35036898 http://dx.doi.org/10.1016/j.iotech.2019.06.003 |