TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

Triggering receptor expressed on myeloid cell 2 (TREM2) is linked to neurodegenerative disease risk. However, the function of TREM2 in neurodegeneration is still not fully understood. Here we investigated the role of microglial TREM2 in TAR-DNA binding protein 43 kDa (TDP-43)-related neurodegenerati...

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Detalles Bibliográficos
Autores principales: Xie, Manling, Liu, Yong U., Zhao, Shunyi, Zhang, Lingxin, Bosco, Dale B., Pang, Yuan-Ping, Zhong, Jun, Sheth, Udit, Martens, Yuka A., Zhao, Na, Liu, Chia-Chen, Zhuang, Yongxian, Wang, Liewei, Dickson, Dennis W., Mattson, Mark P., Bu, Guojun, Wu, Long-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741737/
https://www.ncbi.nlm.nih.gov/pubmed/34916658
http://dx.doi.org/10.1038/s41593-021-00975-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741737/
https://www.ncbi.nlm.nih.gov/pubmed/34916658
http://dx.doi.org/10.1038/s41593-021-00975-6

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