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Amikacin potentiator activity of zinc complexed to a pyrithione derivative with enhanced solubility

Resistance to amikacin in Gram-negatives is usually mediated by the 6'-N-acetyltransferase type Ib [AAC(6')-Ib], which catalyzes the transfer of an acetyl group from acetyl CoA to the 6' position of the antibiotic molecule. A path to continue the effective use of amikacin against resi...

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Detalles Bibliográficos
Autores principales: Magallon, Jesus, Vu, Peter, Reeves, Craig, Kwan, Stella, Phan, Kimberly, Oakley-Havens, Crista L., Rocha, Kenneth, Jimenez, Veronica, Ramirez, María Soledad, Tolmasky, Marcelo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741805/
https://www.ncbi.nlm.nih.gov/pubmed/34997203
http://dx.doi.org/10.1038/s41598-021-04724-4