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Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice

Irisin is well-known to contribute to bone homeostasis due to its bidirectional regulation on osteogenesis and osteoclastogenesis. However, the mechanisms of irisin involved in mesenchymal stem/stromal cells (MSCs)-derived osteogenesis are still under investigated. Fibronectin type III domain-contai...

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Detalles Bibliográficos
Autores principales: Xue, Yuan, Hu, Sihan, Chen, Chichi, He, Jiachen, Sun, Jie, Jin, Yesheng, Zhang, Yuanshu, Zhu, Guoqing, Shi, Qin, Rui, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741853/
https://www.ncbi.nlm.nih.gov/pubmed/35002510
http://dx.doi.org/10.7150/ijbs.63505