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Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia
The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741870/ https://www.ncbi.nlm.nih.gov/pubmed/35028141 http://dx.doi.org/10.1002/ccr3.5212 |
| _version_ | 1784629585260838912 |
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| author | Rizzuto, Giuliana Leoncin, Matteo Imbergamo, Silvia Taurino, Daniela Mico, Maria Caterina Tosi, Manuela Michelato, Anna Buklijas, Ksenija Spinelli, Orietta Lussana, Federico Lessi, Federica Pizzi, Marco Bonaldi, Laura Binotto, Gianni Rambaldi, Alessandro Gurrieri, Carmela |
| author_facet | Rizzuto, Giuliana Leoncin, Matteo Imbergamo, Silvia Taurino, Daniela Mico, Maria Caterina Tosi, Manuela Michelato, Anna Buklijas, Ksenija Spinelli, Orietta Lussana, Federico Lessi, Federica Pizzi, Marco Bonaldi, Laura Binotto, Gianni Rambaldi, Alessandro Gurrieri, Carmela |
| author_sort | Rizzuto, Giuliana |
| collection | PubMed |
| description | The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL. |
| format | Online Article Text |
| id | pubmed-8741870 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-87418702022-01-12 Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia Rizzuto, Giuliana Leoncin, Matteo Imbergamo, Silvia Taurino, Daniela Mico, Maria Caterina Tosi, Manuela Michelato, Anna Buklijas, Ksenija Spinelli, Orietta Lussana, Federico Lessi, Federica Pizzi, Marco Bonaldi, Laura Binotto, Gianni Rambaldi, Alessandro Gurrieri, Carmela Clin Case Rep Case Report The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1‐JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1‐JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL. John Wiley and Sons Inc. 2022-01-07 /pmc/articles/PMC8741870/ /pubmed/35028141 http://dx.doi.org/10.1002/ccr3.5212 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Case Report Rizzuto, Giuliana Leoncin, Matteo Imbergamo, Silvia Taurino, Daniela Mico, Maria Caterina Tosi, Manuela Michelato, Anna Buklijas, Ksenija Spinelli, Orietta Lussana, Federico Lessi, Federica Pizzi, Marco Bonaldi, Laura Binotto, Gianni Rambaldi, Alessandro Gurrieri, Carmela Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title | Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title_full | Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title_fullStr | Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title_full_unstemmed | Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title_short | Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1‐JAK2 positive myeloid sarcoma and acute B‐lymphoblastic leukemia |
| title_sort | sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous pcm1‐jak2 positive myeloid sarcoma and acute b‐lymphoblastic leukemia |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741870/ https://www.ncbi.nlm.nih.gov/pubmed/35028141 http://dx.doi.org/10.1002/ccr3.5212 |
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