Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS

Protein misfolding and aggregation are shared features of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and protein quality control disruption contributes to neuronal toxicity. Therefore, reducing protein aggregation could hold therapeutic potential. We previously identi...

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Detalles Bibliográficos
Autores principales: Luecke, Ian W., Lin, Gloria, Santarriaga, Stephanie, Scaglione, K. Matthew, Ebert, Allison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741877/
https://www.ncbi.nlm.nih.gov/pubmed/34239068
http://dx.doi.org/10.1038/s41434-021-00276-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741877/
https://www.ncbi.nlm.nih.gov/pubmed/34239068
http://dx.doi.org/10.1038/s41434-021-00276-4

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