DNA binding by the antimalarial compound artemisinin

Artemisinin (ART) is a vital medicinal compound that is used alone or as part of a combination therapy against malaria. ART is thought to function by attaching to heme covalently and alkylating a range of proteins. Using a combination of biophysical methods, we demonstrate that ART is bound by three...

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Detalles Bibliográficos
Autores principales: Slavkovic, Sladjana, Shoara, Aron A., Churcher, Zachary R., Daems, Elise, de Wael, Karolien, Sobott, Frank, Johnson, Philip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741894/
https://www.ncbi.nlm.nih.gov/pubmed/34997002
http://dx.doi.org/10.1038/s41598-021-03958-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741894/
https://www.ncbi.nlm.nih.gov/pubmed/34997002
http://dx.doi.org/10.1038/s41598-021-03958-6

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