Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages

HIV-associated neurocognitive disorders (HAND) are prevalent despite combined antiretroviral therapy (cART), affecting 52% of people living with HIV. Our laboratory has demonstrated increased expression of cathepsin B (CATB) in postmortem brain tissue with HAND. Increased secretion of CATB from in v...

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Detalles Bibliográficos
Autores principales: Rosario-Rodríguez, Lester J., Gerena, Yamil, García-Requena, Luis A., Cartagena-Isern, Luz J., Cuadrado-Ruiz, Juan C., Borges-Vélez, Gabriel, Meléndez, Loyda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741953/
https://www.ncbi.nlm.nih.gov/pubmed/34996989
http://dx.doi.org/10.1038/s41598-021-03896-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741953/
https://www.ncbi.nlm.nih.gov/pubmed/34996989
http://dx.doi.org/10.1038/s41598-021-03896-3

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