Cargando…

Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages

HIV-associated neurocognitive disorders (HAND) are prevalent despite combined antiretroviral therapy (cART), affecting 52% of people living with HIV. Our laboratory has demonstrated increased expression of cathepsin B (CATB) in postmortem brain tissue with HAND. Increased secretion of CATB from in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosario-Rodríguez, Lester J., Gerena, Yamil, García-Requena, Luis A., Cartagena-Isern, Luz J., Cuadrado-Ruiz, Juan C., Borges-Vélez, Gabriel, Meléndez, Loyda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741953/ https://www.ncbi.nlm.nih.gov/pubmed/34996989 http://dx.doi.org/10.1038/s41598-021-03896-3

Ejemplares similares

Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
por: Cha, Hye Jin, et al.
Publicado: (2015)

Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
por: Tampus, Reinholdgher, et al.
Publicado: (2015)

Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches
por: Cha, Hye Jin, et al.
Publicado: (2014)

Activation of cannabinoid receptor type 2 by JWH133 alleviates bleomycin-induced pulmonary fibrosis in mice
por: Fu, Qiang, et al.
Publicado: (2017)

Data on individual metabolites of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans
por: Watanabe, Shimpei, et al.
Publicado: (2016)

Modified Alginate-Based Hydrogel as a Carrier of the CB2 Agonist JWH133 for Bone Engineering
por: Zhou, Wei, et al.
Publicado: (2021)

Treatment with CB(2) Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
por: Fraga-Silva, Rodrigo Araujo, et al.
Publicado: (2013)

Pharmacological Properties, Therapeutic Potential and Molecular Mechanisms of JWH133, a CB2 Receptor-Selective Agonist
por: Hashiesh, Hebaallah Mamdouh, et al.
Publicado: (2021)

CB2 Receptor Agonist JWH133 Activates AMPK to Inhibit Growth of C6 Glioma Cells
por: Wang, Feng, et al.
Publicado: (2019)

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
por: Hanlon, Katherine E, et al.
Publicado: (2016)

Chronic Administration of Cannabinoid Receptor 2 Agonist (JWH-133) Increases Ectopic Ovarian Tumor Growth and Endocannabinoids (Anandamide and 2-Arachidonoyl Glycerol) Levels in Immunocompromised SCID Female Mice
por: Blanton, Henry L., et al.
Publicado: (2022)

Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Δ(9)-THC in Rats
por: Uttl, Libor, et al.
Publicado: (2018)

Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy
por: Gupta, Bhavna, et al.
Publicado: (2020)

Acute Pharmacological Effects and Oral Fluid Concentrations of the Synthetic Cannabinoids JWH-122 and JWH-210 in Humans After Self-Administration: An Observational Study
por: Martínez, Lucia, et al.
Publicado: (2021)

Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2022)

Self-Administration of JWH-018 A Synthetic Cannabinoid in Experimentally Naïve Rats
por: Hiranita, Takato
Publicado: (2015)

Correction to: Adolescent self‑administration of the synthetic cannabinoid receptor agonist JWH‑018 induces neurobiological and behavioral alterations in adult male mice
por: Margiani, Giulia, et al.
Publicado: (2023)

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory
por: Li, Ren-shi, et al.
Publicado: (2019)

Natural (∆(9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB(1) receptor
por: Malyshevskaya, Olga, et al.
Publicado: (2017)

Determination of the Synthetic Cannabinoids JWH-122, JWH-210, UR-144 in Oral Fluid of Consumers by GC-MS and Quantification of Parent Compounds and Metabolites by UHPLC-MS/MS
por: La Maida, Nunzia, et al.
Publicado: (2020)

Macrophage Derived Cystatin B/Cathepsin B in HIV Replication and Neuropathogenesis
por: Rivera, Linda E., et al.
Publicado: (2014)

Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways
por: Zenón-Meléndez, Camille N., et al.
Publicado: (2022)

Distribution of Synthetic Cannabinoids JWH-210, RCS-4 and ∆ 9-Tetrahydrocannabinol After Intravenous Administration to Pigs
por: Schaefer, Nadine, et al.
Publicado: (2017)

Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders
por: Theunissen, Eef L., et al.
Publicado: (2019)

Psychotomimetic symptoms after a moderate dose of a synthetic cannabinoid (JWH-018): implications for psychosis
por: Theunissen, Eef L., et al.
Publicado: (2021)

Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
por: Barbieri, Mario, et al.
Publicado: (2022)

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2022)

A selective CB2R agonist (JWH133) protects against pulmonary fibrosis through inhibiting FAK/ERK/S100A4 signaling pathways
por: Wu, Xiao, et al.
Publicado: (2023)

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
por: Brents, Lisa K., et al.
Publicado: (2011)

Cannabinoid receptor 2-selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord
por: Mao, Yanting, et al.
Publicado: (2019)

The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response
por: Delgado-Vélez, Manuel, et al.
Publicado: (2015)

Dysregulation of Macrophage-Secreted Cathepsin B Contributes to HIV-1-Linked Neuronal Apoptosis
por: Rodriguez-Franco, Eillen J., et al.
Publicado: (2012)

Late HIV infection modulates the expression and activity of Cathepsin B, and its inhibitors in macrophages: implications in neuropathogenesis
por: Rodriguez, Eillen, et al.
Publicado: (2010)

HIV Infection Induces Extracellular Cathepsin B Uptake and Damage to Neurons
por: Cantres-Rosario, Yisel M., et al.
Publicado: (2019)

Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine
por: López, Omar Vélez, et al.
Publicado: (2018)

Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor
por: Fechtner, Sabrina, et al.
Publicado: (2019)

Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice
por: Verty, A. N. A., et al.
Publicado: (2015)

Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB(2)
por: Olea-Herrero, N, et al.
Publicado: (2009)

PM291. Synthetic cannabinoid JWH-210 induces motor impairments through the regulation of neurotransmission in tetanus toxin-treated mice
por: Yun, Jaesuk, et al.
Publicado: (2016)

Psychostimulant Effect of the Synthetic Cannabinoid JWH-018 and AKB48: Behavioral, Neurochemical, and Dopamine Transporter Scan Imaging Studies in Mice
por: Ossato, Andrea, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_m66b04k8lbq8sr57hnrvsqdii6