Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia

The formation of the RUNX1-RUNX1T1 fusion protein, resulting from the t(8;21) translocation, is considered to be one of the initiating events of t(8;21) acute myeloid leukemia (AML). However, the mechanisms of the oncogenic mechanism of RUNX1-RUNX1T1 remain unclear. In this study, we found that RUNX...

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Detalles Bibliográficos
Autores principales: Yang, Erna, Guan, Wei, Gong, Desheng, Li, Jieying, Han, Caixia, Zhang, Juan, Wang, Hong, Kang, Synat, Gao, Xuefeng, Li, Yonghui, Yu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741982/
https://www.ncbi.nlm.nih.gov/pubmed/34921223
http://dx.doi.org/10.1038/s12276-021-00695-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741982/
https://www.ncbi.nlm.nih.gov/pubmed/34921223
http://dx.doi.org/10.1038/s12276-021-00695-8

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