Cargando…

Identification of missed viruses by metagenomic sequencing of clinical respiratory samples from Kenya

Pneumonia remains a major cause of mortality and morbidity. Most molecular diagnoses of viruses rely on polymerase chain reaction (PCR) assays that however can fail due to primer mismatch. We investigated the performance of routine virus diagnostics in Kilifi, Kenya, using random-primed viral next g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phan, My V. T., Agoti, Charles N., Munywoki, Patrick K., Otieno, Grieven P., Ngama, Mwanajuma, Kellam, Paul, Cotten, Matthew, Nokes, D. James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742071/ https://www.ncbi.nlm.nih.gov/pubmed/34997042 http://dx.doi.org/10.1038/s41598-021-03987-1

Ejemplares similares

Spread and Evolution of Respiratory Syncytial Virus A Genotype ON1, Coastal Kenya, 2010–2015
por: Otieno, James R., et al.
Publicado: (2017)

Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baseline epidemiological observations
por: Nyiro, Joyce Uchi, et al.
Publicado: (2018)

Molecular characterization of rotavirus group A strains circulating prior to vaccine introduction in rural coastal Kenya, 2002-2013
por: Owor, Betty E., et al.
Publicado: (2019)

Human Coronavirus NL63 Molecular Epidemiology and Evolutionary Patterns in Rural Coastal Kenya
por: Kiyuka, Patience K, et al.
Publicado: (2018)

Molecular Evolutionary Dynamics of Respiratory Syncytial Virus Group A in Recurrent Epidemics in Coastal Kenya
por: Otieno, James R., et al.
Publicado: (2016)

A49 Molecular evolutionary dynamics of respiratory syncytial virus group A in recurrent epidemics in coastal Kenya
por: Otieno, James R., et al.
Publicado: (2017)

Severe Lower Respiratory Tract Infection in Early Infancy and Pneumonia Hospitalizations among Children, Kenya
por: Munywoki, Patrick Kiio, et al.
Publicado: (2013)

Molecular Epidemiology of Human Rhinovirus Infections in Kilifi, Coastal Kenya
por: Onyango, Clayton O, et al.
Publicado: (2012)

Local Evolutionary Patterns of Human Respiratory Syncytial Virus Derived from Whole-Genome Sequencing
por: Agoti, Charles N., et al.
Publicado: (2015)

Genomic analysis of respiratory syncytial virus infections in households and utility in inferring who infects the infant
por: Agoti, Charles N., et al.
Publicado: (2019)

Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis
por: Agoti, Charles N., et al.
Publicado: (2017)

Human Rhinovirus B and C Genomes from Rural Coastal Kenya
por: Agoti, Charles N., et al.
Publicado: (2016)

Surveillance of respiratory viruses among children attending a primary school in rural coastal Kenya
por: Adema, Irene Wangwa, et al.
Publicado: (2020)

Successive Respiratory Syncytial Virus Epidemics in Local Populations Arise from Multiple Variant Introductions, Providing Insights into Virus Persistence
por: Agoti, Charles N., et al.
Publicado: (2015)

Molecular Epidemiology of Human Rhinovirus From 1-Year Surveillance Within a School Setting in Rural Coastal Kenya
por: Luka, Martha M, et al.
Publicado: (2020)

Near-Complete Genome Sequences of Eight Human Astroviruses Recovered from Diarrheal Stool Samples of Hospitalized Children in Coastal Kenya in 2019
por: Lambisia, Arnold W., et al.
Publicado: (2021)

Human metapneumovirus prevalence and patterns of subgroup persistence identified through surveillance of pediatric pneumonia hospital admissions in coastal Kenya, 2007–2016
por: Oketch, John W., et al.
Publicado: (2019)

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance
por: Morobe, John Mwita, et al.
Publicado: (2019)

A34 Spread and evolution of respiratory syncytial virus A genotype ON1, coastal Kenya, 2010–2015
por: Otieno, J R, et al.
Publicado: (2018)

Surveillance of endemic human coronaviruses (HCoV-NL63, OC43 and 229E) associated with childhood pneumonia in Kilifi, Kenya
por: Otieno, Grieven P., et al.
Publicado: (2020)

Continuous Invasion by Respiratory Viruses Observed in Rural Households During a Respiratory Syncytial Virus Seasonal Outbreak in Coastal Kenya
por: Munywoki, Patrick K, et al.
Publicado: (2018)

Epidemiological and evolutionary dynamics of influenza B virus in coastal Kenya as revealed by genomic analysis of strains sampled over a single season
por: Nyasimi, Festus M, et al.
Publicado: (2020)

Infection patterns of endemic human coronaviruses in rural households in coastal Kenya
por: Nyaguthii, Dickson Machira, et al.
Publicado: (2021)

Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
por: Kamau, Everlyn, et al.
Publicado: (2020)

The Source of Respiratory Syncytial Virus Infection In Infants: A Household Cohort Study In Rural Kenya
por: Munywoki, Patrick K., et al.
Publicado: (2014)

Rapid Spread and Diversification of Respiratory Syncytial Virus Genotype ON1, Kenya
por: Agoti, Charles N., et al.
Publicado: (2014)

Correction to: Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
por: Kamau, Everlyn, et al.
Publicado: (2020)

Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009‐2017
por: Owuor, D. Collins, et al.
Publicado: (2020)

The Incidence and Clinical Burden of Respiratory Syncytial Virus Disease Identified through Hospital Outpatient Presentations in Kenyan Children
por: Okiro, Emelda A., et al.
Publicado: (2012)

A27 Using whole genome sequence data and minority variant profiles to elucidate transmission patterns during RSV household outbreaks
por: Githinji, George, et al.
Publicado: (2017)

Integrating epidemiological and genetic data with different sampling intensities into a dynamic model of respiratory syncytial virus transmission
por: Kombe, Ivy K., et al.
Publicado: (2021)

Evolution of respiratory syncytial virus genotype BA in Kilifi, Kenya, 15 years on
por: Kamau, Everlyn, et al.
Publicado: (2020)

An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households
por: Kamau, Everlyn, et al.
Publicado: (2019)

A26 Transmission patterns and evolution of RSV in a community outbreak identified by genomic analysis
por: Agoti, Charles N., et al.
Publicado: (2017)

Genomic epidemiology of the rotavirus G2P[4] strains in coastal Kenya pre- and post-rotavirus vaccine introduction, 2012–8
por: Makori, Timothy O, et al.
Publicado: (2023)

Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010–2018
por: Mwanga, Mike J., et al.
Publicado: (2020)

Whole genome analysis of local Kenyan and global sequences unravels the epidemiological and molecular evolutionary dynamics of RSV genotype ON1 strains
por: Otieno, J R, et al.
Publicado: (2018)

Whole genome analysis of local Kenyan and global sequences unravels the epidemiological and molecular evolutionary dynamics of RSV genotype ON1 strains
por: Otieno, J R, et al.
Publicado: (2018)

Recent sequence variation in probe binding site affected detection of respiratory syncytial virus group B by real-time RT-PCR
por: Kamau, Everlyn, et al.
Publicado: (2017)

Complete Genome Sequences of Dengue Virus Type 2 Strains from Kilifi, Kenya
por: Kamau, Everlyn, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dh9tknn0kckr6knaohn9isikkc