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Targeting STAT3 prevents bile reflux‐induced oncogenic molecular events linked to hypopharyngeal carcinogenesis

The signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to acidic bile present aberrant activation of STAT3, possibly contributing to its oncogenic effect. We hypothesized that S...

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Detalles Bibliográficos
Autores principales: Vageli, Dimitra P., Doukas, Panagiotis G., Siametis, Athanasios, Judson, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742186/
https://www.ncbi.nlm.nih.gov/pubmed/34850540
http://dx.doi.org/10.1111/jcmm.17011