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Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis

BACKGROUND: N6-methyladenosine (m6A) is a dynamic and reversible internal RNA structure of eukaryotic mRNA. YTH domain family 2 (YTHDF2), an m6A-specific reader YTH domain family, plays fundamental roles in several types of cancer. However, the function of YTHDF2 in lung squamous cell carcinoma (LUS...

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Detalles Bibliográficos
Autores principales: Xu, Peng, Hu, Kang, Zhang, Ping, Sun, Zhi-Gang, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742419/
https://www.ncbi.nlm.nih.gov/pubmed/34996459
http://dx.doi.org/10.1186/s12935-021-02368-y