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Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality
BACKGROUND: Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines. Despite their importance in the immune response, and although gasdermin and gasdermin-like genes...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742441/ https://www.ncbi.nlm.nih.gov/pubmed/34996441 http://dx.doi.org/10.1186/s12915-021-01220-z |