A microdosing framework for absolute bioavailability assessment of poorly soluble drugs: A case study on cold‐labeled venetoclax, from chemistry to the clinic

This work presents an end‐to‐end approach for assessing the absolute bioavailability of highly hydrophobic, poorly water‐soluble compounds that exhibit high nonspecific binding using venetoclax as a model drug. The approach utilizes a stable labeled i.v. microdose and requires fewer resources compar...

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Detalles Bibliográficos
Autores principales: Alaarg, Amr, Menon, Rajeev, Rizzo, David, Liu, Yemin, Bien, Jeffrey, Elkinton, Tricia, Grieme, Timothy, Asmus, Lutz R., Salem, Ahmed Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742638/
https://www.ncbi.nlm.nih.gov/pubmed/34416076
http://dx.doi.org/10.1111/cts.13144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742638/
https://www.ncbi.nlm.nih.gov/pubmed/34416076
http://dx.doi.org/10.1111/cts.13144

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