Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers

Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic CL (CL(int)) often leads to significant challenges in evaluating the pharmacokinetics of such compounds. Although in vitro–in vivo extrapolati...

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Detalles Bibliográficos
Autores principales: Yoshida, Kosuke, Doi, Yuki, Iwazaki, Norihiko, Yasuhara, Hidenori, Ikenaga, Yuka, Shimizu, Hidetoshi, Nakada, Tomohisa, Watanabe, Tomoko, Tateno, Chise, Sanoh, Seigo, Kotake, Yaichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742647/
https://www.ncbi.nlm.nih.gov/pubmed/34080287
http://dx.doi.org/10.1111/cts.13070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742647/
https://www.ncbi.nlm.nih.gov/pubmed/34080287
http://dx.doi.org/10.1111/cts.13070

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