A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage

As vaccine-induced non-neutralizing antibodies may cause antibody-dependent enhancement of Zika virus (ZIKV) infection, we test a vaccine that induces only specific cytotoxic T lymphocytes (CTLs) without specific antibodies. We construct a DNA vaccine expressing a ubiquitinated and rearranged ZIKV n...

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Detalles Bibliográficos
Autores principales: Gambino, Frank, Tai, Wanbo, Voronin, Denis, Zhang, Yi, Zhang, Xiujuan, Shi, Juan, Wang, Xinyi, Wang, Ning, Du, Lanying, Qiao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742672/
https://www.ncbi.nlm.nih.gov/pubmed/33979612
http://dx.doi.org/10.1016/j.celrep.2021.109107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742672/
https://www.ncbi.nlm.nih.gov/pubmed/33979612
http://dx.doi.org/10.1016/j.celrep.2021.109107

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