Hunting for Beneficial Mutations: Conditioning on SIFT Scores When Estimating the Distribution of Fitness Effect of New Mutations

The distribution of fitness effects (DFE) of new mutations is a key parameter of molecular evolution. The DFE can in principle be estimated by comparing the site frequency spectra (SFS) of putatively neutral and functional polymorphisms. Unfortunately, the DFE is intrinsically hard to estimate, espe...

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Detalles Bibliográficos
Autores principales: Chen, Jun, Bataillon, Thomas, Glémin, Sylvain, Lascoux, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743036/
https://www.ncbi.nlm.nih.gov/pubmed/34180988
http://dx.doi.org/10.1093/gbe/evab151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743036/
https://www.ncbi.nlm.nih.gov/pubmed/34180988
http://dx.doi.org/10.1093/gbe/evab151

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