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How much do smear-negative patients really contribute to tuberculosis transmissions? Re-examining an old question with new tools

BACKGROUND: Sputum smear microscopy is a common surrogate for tuberculosis infectiousness. Previous estimates that smear-negative patients contribute 13–20% of transmissions and are, on average, 20 to 25% as infectious as smear-positive cases are understood to be high. Herein, we use an ideal real-w...

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Detalles Bibliográficos
Autores principales: Asadi, Leyla, Croxen, Matthew, Heffernan, Courtney, Dhillon, Mannat, Paulsen, Catherine, Egedahl, Mary Lou, Tyrrell, Greg, Doroshenko, Alexander, Long, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743225/
https://www.ncbi.nlm.nih.gov/pubmed/35036885
http://dx.doi.org/10.1016/j.eclinm.2021.101250