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Systematic identification of ACE2 expression modulators reveals cardiomyopathy as a risk factor for mortality in COVID-19 patients

BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for SARS-CoV-2. It plays critical roles in both the transmission and the pathogenesis of COVID-19. Comprehensive profiling of ACE2 expression patterns could reveal risk factors of severe COVID-19 illness. While the express...

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Detalles Bibliográficos
Autores principales: Kaur, Navchetan, Oskotsky, Boris, Butte, Atul J., Hu, Zicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743438/
https://www.ncbi.nlm.nih.gov/pubmed/35012625
http://dx.doi.org/10.1186/s13059-021-02589-4