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Real-time digital polymerase chain reaction (PCR) as a novel technology improves limit of detection for rare allele assays
BACKGROUND: Tumor heterogeneity may lead to false negative test results for tissue biopsy-based companion diagnostic tests. Real-time polymerase chain reaction (PCR) and digital PCR assays are used to detect rare alleles in cell-free circulating DNA for liquid biopsies; however, those tests lack str...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743530/ https://www.ncbi.nlm.nih.gov/pubmed/35070745 http://dx.doi.org/10.21037/tlcr-21-728 |