CaMKII inhibitor KN‐93 impaired angiogenesis and aggravated cardiac remodelling and heart failure via inhibiting NOX2/mtROS/p‐VEGFR2 and STAT3 pathways

Persistent cardiac Ca(2+)/calmodulin‐dependent Kinase II (CaMKII) activation was considered to promote heart failure (HF) development, some studies believed that CaMKII was a target for therapy of HF. However, CaMKII was an important mediator for the ischaemia‐induced coronary angiogenesis, and new...

Descripción completa

Detalles Bibliográficos
Autores principales: Ni, Yajuan, Deng, Jie, Bai, Hongyuan, Liu, Chang, Liu, Xin, Wang, Xiaofang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743652/
https://www.ncbi.nlm.nih.gov/pubmed/34845819
http://dx.doi.org/10.1111/jcmm.17081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8743652/
https://www.ncbi.nlm.nih.gov/pubmed/34845819
http://dx.doi.org/10.1111/jcmm.17081

Ejemplares similares