Cargando…

Neurological management and work-up of neurotoxicity associated with CAR T cell therapy

INTRODUCTION: Treatment with CD19 chimeric antigen receptor (CAR) T cells is an innovative therapeutic approach for patients with relapsed/refractory diffuse large B cell lymphoma (r/rDLBCL) and B-lineage acute lymphoblastic leukemia (r/rALL). However, convincing therapeutic response rates can be ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Möhn, Nora, Bonda, Viktoria, Grote-Levi, Lea, Panagiota, Victoria, Fröhlich, Tabea, Schultze-Florey, Christian, Wattjes, Mike P., Beutel, Gernot, Eder, Matthias, David, Sascha, Körner, Sonja, Höglinger, Günter, Stangel, Martin, Ganser, Arnold, Koenecke, Christian, Skripuletz, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744256/ https://www.ncbi.nlm.nih.gov/pubmed/35000613 http://dx.doi.org/10.1186/s42466-021-00166-5

Ejemplares similares

(18)F-FDG PET/CT of off-target lymphoid organs in CD19-targeting chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma
por: Derlin, Thorsten, et al.
Publicado: (2020)

Monocyte chemoattractant protein 1 as a potential biomarker for immune checkpoint inhibitor‐associated neurotoxicity
por: Möhn, Nora, et al.
Publicado: (2023)

Mild COVID-19 symptoms despite treatment with teriflunomide and high-dose methylprednisolone due to multiple sclerosis relapse
por: Möhn, Nora, et al.
Publicado: (2020)

Diagnosis and Differential Diagnosis of Neurological Adverse Events during Immune Checkpoint Inhibitor Therapy
por: Möhn, Nora, et al.
Publicado: (2020)

The graft-versus-leukemia effect of prophylactic donor lymphocyte infusions after allogeneic stem cell transplantation is equally effective in relapse prevention but safer compared to spontaneous graft-versus-host disease
por: Stadler, Michael, et al.
Publicado: (2023)

MRD as Biomarker for Response to Donor Lymphocyte Infusion after Allogeneic Hematopoietic Cell Transplantation in Patients with AML
por: Teich, Katrin, et al.
Publicado: (2023)

Navigating preemptive and therapeutic donor lymphocyte infusions in advanced myeloid malignancies by high-sensitivity chimerism analysis
por: Stadler, Michael, et al.
Publicado: (2022)

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2022)

Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry
por: Schultze-Florey, Christian R., et al.
Publicado: (2021)

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy
por: Hopfner, Franziska, et al.
Publicado: (2021)

Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
por: Grote-Levi, Lea, et al.
Publicado: (2023)

PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2021)

Neurological Immune Related Adverse Events Associated with Nivolumab, Ipilimumab, and Pembrolizumab Therapy—Review of the Literature and Future Outlook
por: Möhn, Nora, et al.
Publicado: (2019)

Healthy-like CD4(+) Regulatory and CD4(+) Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion
por: Schneider, Jessica, et al.
Publicado: (2022)

Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation
por: Hümmert, Martin W., et al.
Publicado: (2021)

Spectral flow cytometry cluster analysis of therapeutic donor lymphocyte infusions identifies T cell subsets associated with outcome in patients with AML relapse
por: Odak, Ivan, et al.
Publicado: (2022)

Complications after CD19+ CAR T-Cell Therapy
por: Penack, Olaf, et al.
Publicado: (2020)

Clonal expansion of CD8(+) T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI
por: Schultze-Florey, Christian R., et al.
Publicado: (2021)

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
por: Gudi, Viktoria, et al.
Publicado: (2014)

Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy
por: Ravens, Sarina, et al.
Publicado: (2018)

Therapy with cladribine is efficient and safe in patients previously treated with natalizumab
por: Möhn, Nora, et al.
Publicado: (2019)

Clinicopathologic Findings in Fatal Neurotoxicity After Adoptive Immunotherapy With CD19-Directed CAR T-Cells
por: Karschnia, Philipp, et al.
Publicado: (2021)

Mesenchymal stem cells require the peripheral immune system for immunomodulating effects in animal models of multiple sclerosis
por: Salinas Tejedor, Laura, et al.
Publicado: (2016)

Cytokines in CAR T Cell–Associated Neurotoxicity
por: Gust, Juliane, et al.
Publicado: (2020)

Neurofilament light chain serum levels correlate with the severity of neurotoxicity after CAR T-cell treatment
por: Schoeberl, Florian, et al.
Publicado: (2022)

Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2019)

Implications of COVID-19 Outbreak on Immune Therapies in Multiple Sclerosis Patients—Lessons Learned From SARS and MERS
por: Möhn, Nora, et al.
Publicado: (2020)

Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
por: Gudi, Viktoria, et al.
Publicado: (2021)

Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease
por: Schultze-Florey, Rebecca E., et al.
Publicado: (2018)

Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis
por: Schwenkenbecher, Philipp, et al.
Publicado: (2019)

Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up
por: Shahswar, Rabia, et al.
Publicado: (2020)

Neuro-Sjögren: Peripheral Neuropathy With Limb Weakness in Sjögren's Syndrome
por: Seeliger, Tabea, et al.
Publicado: (2019)

Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy
por: Luo, Yi, et al.
Publicado: (2020)

Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases
por: Möhn, Nora, et al.
Publicado: (2020)

Differentiation of viral and autoimmune central nervous system inflammation by kynurenine pathway
por: Luo, Yi, et al.
Publicado: (2021)

Novel pathophysiological insights into CAR-T cell associated neurotoxicity
por: Genoud, Vassilis, et al.
Publicado: (2023)

Editorial: Novel insights into CAR T-cell associated neurotoxicity
por: Bouziana, Stella
Publicado: (2023)

Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti-CD19 CAR T-cell Treated Patients
por: Panagiota, Victoria, et al.
Publicado: (2023)

Hearing dysfunction in patients with Neuro-Sjögren: a cross-sectional study
por: Seeliger, Tabea, et al.
Publicado: (2020)

Reappearance of effector T cells is associated with recovery from COVID-19
por: Odak, Ivan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s7s89reemsbfgdcphml8qpc9gd