Cargando…

RNA binding protein HuD promotes autophagy and tumor stress survival by suppressing mTORC1 activity and augmenting ARL6IP1 levels

BACKGROUND: Neuronal-origin HuD (ELAVL4) is an RNA binding protein overexpressed in neuroblastoma (NB) and certain other cancers. The RNA targets of this RNA binding protein in neuroblastoma cells and their role in promoting cancer survival have been unexplored. In the study of modulators of mTORC1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bishayee, Kausik, Habib, Khadija, Nazim, Uddin Md., Kang, Jieun, Szabo, Aniko, Huh, Sung-Oh, Sadra, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744261/ https://www.ncbi.nlm.nih.gov/pubmed/35012594 http://dx.doi.org/10.1186/s13046-021-02203-2

Ejemplares similares

Correction to: RNA binding protein HuD promotes autophagy and tumor stress survival by suppressing mTORC1 activity and augmenting ARL6IP1 levels
por: Bishayee, Kausik, et al.
Publicado: (2022)

mTORC1-Inhibition Potentiating Metabolic Block by Tyrosine Kinase Inhibitor Ponatinib in Multiple Myeloma
por: Nazim, Uddin Md., et al.
Publicado: (2022)

RNA Binding Protein Rbms1 Enables Neuronal Differentiation and Radial Migration during Neocortical Development by Binding and Stabilizing the RNA Message for Efr3a
por: Habib, Khadija, et al.
Publicado: (2022)

Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1
por: Sosanya, Natasha M., et al.
Publicado: (2013)

HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA
por: Tebaldi, Toma, et al.
Publicado: (2018)

Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
por: Choi, Seunghyuk, et al.
Publicado: (2019)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

Tolerance to the Neuron-Specific Paraneoplastic HuD Antigen
por: DeLuca, Ilana, et al.
Publicado: (2009)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members
por: Wang, Huiwen, et al.
Publicado: (2010)

Functional and direct interaction between the RNA binding protein HuD and active Akt1
por: Fujiwara, Toshinobu, et al.
Publicado: (2012)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

No evidence for circulating HuD-specific CD8(+) T cells in patients with paraneoplastic neurological syndromes and Hu antibodies
por: de Beukelaar, Janet W., et al.
Publicado: (2007)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Expression of HuD (a paraneoplastic encephalomyelitis antigen) mRNA in lung cancer.
por: Cho, J. H., et al.
Publicado: (1997)

Intratumoral anti-HuD immunotoxin therapy for small cell lung cancer and neuroblastoma
por: Ehrlich, Debra, et al.
Publicado: (2014)

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis
por: De Santis, Riccardo, et al.
Publicado: (2019)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Azoxystrobin Impairs Neuronal Migration and Induces ROS Dependent Apoptosis in Cortical Neurons
por: Kang, Jieun, et al.
Publicado: (2021)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Transcriptional regulation of mTORC1 in cancer
por: Di Malta, Chiara, et al.
Publicado: (2018)

Regulation of mTORC1 by Upstream Stimuli
por: Melick, Chase H., et al.
Publicado: (2020)

Crosstalk of Hedgehog and mTORC1 Pathways
por: Larsen, Lasse Jonsgaard, et al.
Publicado: (2020)

Regulation of mTORC1 by the Rag GTPases
por: Lama-Sherpa, Tshering D., et al.
Publicado: (2023)

A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
por: Khamsing, Dany, et al.
Publicado: (2021)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction
por: Bronicki, Lucas M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_b3mc8e23a3ohfobn9fuo89knnl