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Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder
BACKGROUND/AIM: The polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as alcohol use disorder that is influenced by a combination of multiple variants, each of which has a very small effect. Yet, conventional PRS methods...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744290/ https://www.ncbi.nlm.nih.gov/pubmed/35012447 http://dx.doi.org/10.1186/s12859-022-04566-5 |