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Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder

BACKGROUND/AIM: The polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as alcohol use disorder that is influenced by a combination of multiple variants, each of which has a very small effect. Yet, conventional PRS methods...

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Detalles Bibliográficos
Autores principales:	Yang, James J., Luo, Xi, Trucco, Elisa M., Buu, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744290/ https://www.ncbi.nlm.nih.gov/pubmed/35012447 http://dx.doi.org/10.1186/s12859-022-04566-5

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