Cargando…

Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes

BACKGROUND: Alternative splicing is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and how this affects cellular differentiation remains unclear. Long read seq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, David J., Hall, Nicola A. L., Irish, Naomi, Man, Angela L., Glynn, Will, Mould, Arne, Angeles, Alejandro De Los, Angiolini, Emily, Swarbreck, David, Gharbi, Karim, Tunbridge, Elizabeth M., Haerty, Wilfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744310/ https://www.ncbi.nlm.nih.gov/pubmed/35012468 http://dx.doi.org/10.1186/s12864-021-08261-2

Ejemplares similares

Correction to: Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
por: Wright, David J., et al.
Publicado: (2022)

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain
por: Clark, Michael B., et al.
Publicado: (2019)

Roadblock: improved annotations do not necessarily translate into new functional insights
por: Hall, Nicola A. L., et al.
Publicado: (2021)

Isoform Age - Splice Isoform Profiling Using Long-Read Technologies
por: De Paoli-Iseppi, Ricardo, et al.
Publicado: (2021)

Corrigendum: Isoform Age - Splice Isoform Profiling Using Long-Read Technologies
por: De Paoli-Iseppi, Ricardo, et al.
Publicado: (2021)

Single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells
por: Mincarelli, Laura, et al.
Publicado: (2023)

Unexpected selection to retain high GC content and splicing enhancers within exons of multiexonic lncRNA loci
por: Haerty, Wilfried, et al.
Publicado: (2015)

Cellular calcium in bipolar disorder: systematic review and meta-analysis
por: Harrison, Paul J., et al.
Publicado: (2019)

RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts
por: Li, Yang I., et al.
Publicado: (2015)

Chromosome-level genome sequence of the Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) highlights regions of introgression with O. mossambicus
por: Etherington, G. J., et al.
Publicado: (2022)

Long‐Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor‐Specific Isoforms
por: Chen, Hui, et al.
Publicado: (2019)

Freddie: annotation-independent detection and discovery of transcriptomic alternative splicing isoforms using long-read sequencing
por: Orabi, Baraa, et al.
Publicado: (2022)

Assessing the functional relevance of splice isoforms
por: Pozo, Fernando, et al.
Publicado: (2021)

Structures of alternatively spliced isoforms of human ketohexokinase
por: Trinh, Chi H., et al.
Publicado: (2009)

Efficient and accurate detection of splice junctions from RNA-seq with Portcullis
por: Mapleson, Daniel, et al.
Publicado: (2018)

Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing
por: Cavelier, Lucia, et al.
Publicado: (2015)

Analysis of transcripts and splice isoforms in red clover (Trifolium pratense L.) by single-molecule long-read sequencing
por: Chao, Yuehui, et al.
Publicado: (2018)

APPRIS: annotation of principal and alternative splice isoforms
por: Rodriguez, Jose Manuel, et al.
Publicado: (2013)

EASI—enrichment of alternatively spliced isoforms
por: Venables, Julian P., et al.
Publicado: (2006)

A Network of Splice Isoforms for the Mouse
por: Li, Hong-Dong, et al.
Publicado: (2016)

Assessment of orthologous splicing isoforms in human and mouse orthologous genes
por: Zambelli, Federico, et al.
Publicado: (2010)

A rather dry subject; investigating the study of arid-associated microbial communities
por: Osborne, Peter, et al.
Publicado: (2020)

Genome-wide discovery of human splicing branchpoints
por: Mercer, Tim R., et al.
Publicado: (2015)

Alternative splicing results in RET isoforms with distinct trafficking properties
por: Richardson, Douglas S., et al.
Publicado: (2012)

Alternative Splicing and Isoforms: From Mechanisms to Diseases
por: Liu, Qi, et al.
Publicado: (2022)

LIQA: long-read isoform quantification and analysis
por: Hu, Yu, et al.
Publicado: (2021)

Single-molecule long-read sequencing analysis improves genome annotation and sheds new light on the transcripts and splice isoforms of Zoysia japonica
por: Guan, Jin, et al.
Publicado: (2022)

Accurate isoform discovery with IsoQuant using long reads
por: Prjibelski, Andrey D., et al.
Publicado: (2023)

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
por: Angiolini, Francesca, et al.
Publicado: (2019)

MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery
por: Wang, Kai, et al.
Publicado: (2010)

Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2
por: MacNicol, Melanie C., et al.
Publicado: (2017)

Splice isoform estrogen receptors as integral transmembrane proteins
por: Kim, Kyung Hee, et al.
Publicado: (2011)

Evolution of the Plasma and Tissue Kallikreins, and Their Alternative Splicing Isoforms
por: Koumandou, Vassiliki Lila, et al.
Publicado: (2013)

Functional impact of splice isoform diversity in individual cells
por: Yap, Karen, et al.
Publicado: (2016)

Tau Isoforms: Gaining Insight into MAPT Alternative Splicing
por: Corsi, Andrea, et al.
Publicado: (2022)

Increased Polymorphism Near Low-Complexity Sequences across the Genomes of Plasmodium falciparum Isolates
por: Haerty, Wilfried, et al.
Publicado: (2011)

Mutations within lncRNAs are effectively selected against in fruitfly but not in human
por: Haerty, Wilfried, et al.
Publicado: (2013)

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys
por: Newman, Ruchi M., et al.
Publicado: (2008)

Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing
por: Avale, María Elena, et al.
Publicado: (2013)

P446: COMPREHENSIVE CHARACTERIZATION OF DIFFERENTIAL GENE EXPRESSION AND ISOFORM USAGE IN SPLICING FACTOR-MUTATED ACUTE MYELOID LEUKEMIA USING LONG-READ SEQUENCING
por: Thieme, Susanne, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pbruffjpqva825cd6ip2eaq9ca