Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation

Spindle cell/sclerosing rhabdomyosarcoma (ssRMS) is a rare subtype of rhabdomyosarcoma, commonly harboring a gain-of-function L122R mutation in the muscle-specific master transcription factor MYOD1. MYOD1-mutated ssRMS is almost invariably fatal, and development of novel therapeutic approaches based...

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Detalles Bibliográficos
Autores principales: Choo, Florence, Odinstov, Igor, Nusser, Kevin, Nicholson, Katelyn S., Davis, Lara, Corless, Christopher L., Stork, Linda, Somwar, Romel, Ladanyi, Marc, Davis, Jessica L., Davare, Monika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744497/
https://www.ncbi.nlm.nih.gov/pubmed/35012940
http://dx.doi.org/10.1101/mcs.a006140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744497/
https://www.ncbi.nlm.nih.gov/pubmed/35012940
http://dx.doi.org/10.1101/mcs.a006140

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