The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory

Energy sensors mTORC1 and AMPKα1 regulate T-cell metabolism and differentiation, while rapamycin (Rapa)-inhibition of mTORC1 (RIM) promotes T-cell memory. However, the underlying pathway and the role of AMPKα1 in Rapa-induced T-cell memory remain elusive. Using genetic and pharmaceutical tools, we d...

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Detalles Bibliográficos
Autores principales: Ara, Anjuman, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C., Islam, Md. Fahmid, Wu, Zhaojia, Chibbar, Rajni, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744613/
https://www.ncbi.nlm.nih.gov/pubmed/35008461
http://dx.doi.org/10.3390/ijms23010037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744613/
https://www.ncbi.nlm.nih.gov/pubmed/35008461
http://dx.doi.org/10.3390/ijms23010037

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