Cargando…

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation

A lucanthone, one of the family of thioxanthenones, has been reported for its inhibitory effects of apurinic endonuclease-1 and autophagy. In this study, we investigated whether lucanthone could enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in various canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoon, Ji Yun, Woo, Seon Min, Seo, Seung Un, Song, So Rae, Lee, Seul Gi, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744864/ https://www.ncbi.nlm.nih.gov/pubmed/35008442 http://dx.doi.org/10.3390/ijms23010017

Ejemplares similares

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
por: Wu, Kaixin, et al.
Publicado: (2021)

Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation
por: Song, So Rae, et al.
Publicado: (2023)

Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells
por: Woo, Seon Min, et al.
Publicado: (2020)

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells
por: Woo, Seon Min, et al.
Publicado: (2015)

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
por: Woo, Seon Min, et al.
Publicado: (2022)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells
por: Shahriyar, Sk Abrar, et al.
Publicado: (2018)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway
por: Woo, Seon Min, et al.
Publicado: (2019)

Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
por: Shahriyar, Sk Abrar, et al.
Publicado: (2020)

Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin
por: Lee, Tak Gyeom, et al.
Publicado: (2023)

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
por: Kim, Seok, et al.
Publicado: (2018)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
por: Yun, Jeong Mi, et al.
Publicado: (2018)

Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
por: Woo, Seon Min, et al.
Publicado: (2019)

Proceedings: Effect of lucanthone on the radiosensitivity of a mouse tumour.
por: Rao, K. R., et al.
Publicado: (1975)

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells
por: Jeon, Mi-Yeon, et al.
Publicado: (2020)

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer
por: Morgan, Ethan L., et al.
Publicado: (2021)

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP
por: Kim, Seok, et al.
Publicado: (2019)

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin
por: Seo, Seung Un, et al.
Publicado: (2017)

Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation
por: Woo, Seon Min, et al.
Publicado: (2019)

Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity
por: Tonelli, Michele, et al.
Publicado: (2020)

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells
por: Zhu, Zhi-Chuan, et al.
Publicado: (2019)

Apoptotic resistance of human skin mast cells is mediated by Mcl-1
por: Hazzan, Tarek, et al.
Publicado: (2017)

YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
por: Woo, Seon Min, et al.
Publicado: (2016)

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells
por: Park, Eun Jung, et al.
Publicado: (2016)

Dubbing
por: Sibthorpe, Charles
Publicado: (1880)

Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression
por: Jeon, Mi-Yeon, et al.
Publicado: (2017)

Hispidulin Enhances TRAIL-Mediated Apoptosis via CaMKKβ/AMPK/USP51 Axis-Mediated Bim Stabilization
por: Woo, Seon Min, et al.
Publicado: (2019)

Downregulation of c-FLIP and upregulation of DR-5 by cantharidin sensitizes TRAIL-mediated apoptosis in prostate cancer cells via autophagy flux
por: Nazim, Uddin Md, et al.
Publicado: (2020)

Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells
por: Kim, So-Young, et al.
Publicado: (2015)

Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells
por: Willms, Anna, et al.
Publicado: (2019)

TRAIL is involved in CpG ODN-mediated anti-apoptotic signals
por: LIM, EUN-JUNG, et al.
Publicado: (2011)

Proceedings: Interaction of tetracycline and lucanthone on radiation damage in mammalian embryos as dependent on LET (experiments with pions).
por: Fritz-Niggli, H., et al.
Publicado: (1975)

Lucanthone Targets Lysosomes to Perturb Glioma Proliferation, Chemoresistance and Stemness, and Slows Tumor Growth In Vivo
por: Radin, Daniel P., et al.
Publicado: (2022)

Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mTOR/S6K1-Mediated Downregulation of Mcl-1
por: Zhang, Tao, et al.
Publicado: (2014)

Dubbing: / An analysis of idiomatic expressions in "Coco".
por: Tolentino Cruz, Ana María
Publicado: (2018)

The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1
por: Wu, Kaixin, et al.
Publicado: (2020)

Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
por: Abd-Rabou, Ahmed A, et al.
Publicado: (2021)

Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding
por: Naidu, Mamta D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_slhku3804er5320e7t32ksfc25