A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members

The SKP1, CUL1, F-box protein (SCF) complex represents a family of 69 E3 ubiquitin ligases that poly-ubiquitinate protein substrates marking them for proteolytic degradation via the 26S proteasome. Established SCF complex targets include transcription factors, oncoproteins and tumor suppressors that...

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Detalles Bibliográficos
Autores principales: Campos Gudiño, Rubi, Farrell, Ally C., Neudorf, Nicole M., McManus, Kirk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744973/
https://www.ncbi.nlm.nih.gov/pubmed/35008511
http://dx.doi.org/10.3390/ijms23010084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744973/
https://www.ncbi.nlm.nih.gov/pubmed/35008511
http://dx.doi.org/10.3390/ijms23010084

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