E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL

Targeted disruption of E2f2 in mice causes T-cell hyperactivation and a disproportionate cell cycle entry upon stimulation. However, E2f2(−/−) mice do not develop a lymphoproliferative condition. We report that E2f2 plays a Fas-dependent anti-apoptotic function in vitro and in vivo. TCR-stimulated m...

Descripción completa

Detalles Bibliográficos
Autores principales: Mustafa, Noor, Mitxelena, Jone, Infante, Arantza, Zenarruzabeitia, Olatz, Eriz, Ainhoa, Iglesias-Ara, Ainhoa, Zubiaga, Ana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745065/
https://www.ncbi.nlm.nih.gov/pubmed/35008734
http://dx.doi.org/10.3390/ijms23010311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745065/
https://www.ncbi.nlm.nih.gov/pubmed/35008734
http://dx.doi.org/10.3390/ijms23010311

Ejemplares similares