Structure-Based Design of an RNase Chimera for Antimicrobial Therapy

Bacterial resistance to antibiotics urges the development of alternative therapies. Based on the structure-function of antimicrobial members of the RNase A superfamily, we have developed a hybrid enzyme. Within this family, RNase 1 exhibits the highest catalytic activity and the lowest cytotoxicity;...

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Detalles Bibliográficos
Autores principales: Prats-Ejarque, Guillem, Lorente, Helena, Villalba, Clara, Anguita, Raúl, Lu, Lu, Vázquez-Monteagudo, Sergi, Fernández-Millán, Pablo, Boix, Ester
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745102/
https://www.ncbi.nlm.nih.gov/pubmed/35008522
http://dx.doi.org/10.3390/ijms23010095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745102/
https://www.ncbi.nlm.nih.gov/pubmed/35008522
http://dx.doi.org/10.3390/ijms23010095

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