Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury

Microglia/astrocyte and B cell neuroimmune responses are major contributors to the neurological deficits after traumatic spinal cord injury (SCI). Bruton tyrosine kinase (BTK) activation mechanistically links these neuroimmune mechanisms. Our objective is to use Ibrutinib, an FDA-approved BTK inhibi...

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Detalles Bibliográficos
Autores principales: Yu, Chen Guang, Bondada, Vimala, Iqbal, Hina, Moore, Kate L., Gensel, John C., Bondada, Subbarao, Geddes, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745213/
https://www.ncbi.nlm.nih.gov/pubmed/35008785
http://dx.doi.org/10.3390/ijms23010355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745213/
https://www.ncbi.nlm.nih.gov/pubmed/35008785
http://dx.doi.org/10.3390/ijms23010355

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