Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms

Different 2,4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selectivity. Un-substituted phenyl-bearing coumari...

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Detalles Bibliográficos
Autores principales: Eldehna, Wagdy M., Taghour, Mohammed S., Al-Warhi, Tarfah, Nocentini, Alessio, Elbadawi, Mostafa M., Mahdy, Hazem A., Abdelrahman, Mohamed A., Alotaibi, Ohoud J., Aljaeed, Nada, Elimam, Diaaeldin M., Afarinkia, Kamyar, Abdel-Aziz, Hatem A., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745369/
https://www.ncbi.nlm.nih.gov/pubmed/34991416
http://dx.doi.org/10.1080/14756366.2021.2024528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745369/
https://www.ncbi.nlm.nih.gov/pubmed/34991416
http://dx.doi.org/10.1080/14756366.2021.2024528

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