Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function

Plakin repeat domains (PRDs) are globular modules that mediate the interaction of plakin proteins with the intermediate filament (IF) cytoskeleton. These associations are vital for maintaining tissue integrity in cardiac muscle and epithelial tissues. PRDs are subject to mutations that give rise to...

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Detalles Bibliográficos
Autores principales: Mohammed, Fiyaz, Odintsova, Elena, Chidgey, Martyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745463/
https://www.ncbi.nlm.nih.gov/pubmed/35008956
http://dx.doi.org/10.3390/ijms23010529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745463/
https://www.ncbi.nlm.nih.gov/pubmed/35008956
http://dx.doi.org/10.3390/ijms23010529

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