Is Protein Folding a Thermodynamically Unfavorable, Active, Energy-Dependent Process?

The prevailing current view of protein folding is the thermodynamic hypothesis, under which the native folded conformation of a protein corresponds to the global minimum of Gibbs free energy G. We question this concept and show that the empirical evidence behind the thermodynamic hypothesis of foldi...

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Detalles Bibliográficos
Autores principales: Sorokina, Irina, Mushegian, Arcady R., Koonin, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745595/
https://www.ncbi.nlm.nih.gov/pubmed/35008947
http://dx.doi.org/10.3390/ijms23010521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745595/
https://www.ncbi.nlm.nih.gov/pubmed/35008947
http://dx.doi.org/10.3390/ijms23010521

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