Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism

Upon depolarization of chromaffin cells (CCs), a prompt release of catecholamines occurs. This event is triggered by a subplasmalemmal high-Ca(2+) microdomain (HCMD) generated by Ca(2+) entry through nearby voltage-activated calcium channels. HCMD is efficiently cleared by local mitochondria that av...

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Detalles Bibliográficos
Autores principales: de Pascual, Ricardo, Calzaferri, Francesco, Gonzalo, Paula C., Serrano-Nieto, Rubén, de los Ríos, Cristóbal, García, Antonio G., Gandía, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745631/
https://www.ncbi.nlm.nih.gov/pubmed/35008868
http://dx.doi.org/10.3390/ijms23010440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745631/
https://www.ncbi.nlm.nih.gov/pubmed/35008868
http://dx.doi.org/10.3390/ijms23010440

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