Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS

Background: Enzymes of tricarboxylic acid (TCA) have recently been recognized as tumor suppressors. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) cause pheochromocytomas and paragangliomas (PCCs/PGLs) and predispose patients to malignant disease with poor prognosis. Methods: Using t...

Descripción completa

Detalles Bibliográficos
Autores principales: Tabebi, Mouna, Kumar Dutta, Ravi, Skoglund, Camilla, Söderkvist, Peter, Gimm, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745660/
https://www.ncbi.nlm.nih.gov/pubmed/35008989
http://dx.doi.org/10.3390/ijms23010560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745660/
https://www.ncbi.nlm.nih.gov/pubmed/35008989
http://dx.doi.org/10.3390/ijms23010560

Ejemplares similares