DUSP-1 Induced by PGE(2) and PGE(1) Attenuates IL-1β-Activated MAPK Signaling, Leading to Suppression of NGF Expression in Human Intervertebral Disc Cells

The molecular mechanism of discogenic low back pain (LBP) involves nonphysiological nerve invasion into a degenerated intervertebral disc (IVD), induced by nerve growth factor (NGF). Selective cyclooxygenase (COX)-2 inhibitors are mainly used in the treatment of LBP, and act by suppressing the infla...

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Detalles Bibliográficos
Autores principales: Kusakabe, Takuya, Sawaji, Yasunobu, Endo, Kenji, Suzuki, Hidekazu, Konishi, Takamitsu, Maekawa, Asato, Murata, Kazuma, Yamamoto, Kengo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745672/
https://www.ncbi.nlm.nih.gov/pubmed/35008797
http://dx.doi.org/10.3390/ijms23010371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745672/
https://www.ncbi.nlm.nih.gov/pubmed/35008797
http://dx.doi.org/10.3390/ijms23010371

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