Cargando…

Altered HIV-1 mRNA Splicing Due to Drug-Resistance-Associated Mutations in Exon 2/2b

The underlying molecular mechanism and their general effect on the replication capacity of HIV 1 drug-resistance-associated mutations is often poorly understood. To elucidate the effect of two such mutations located in a region with a high density of spicing regulatory elements on the HIV-1-splicing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müller, Lisa, Moskorz, Wiebke, Brillen, Anna-Lena, Hillebrand, Frank, Ostermann, Philipp Niklas, Kiel, Niklas, Walotka, Lara, Ptok, Johannes, Timm, Jörg, Lübke, Nadine, Schaal, Heiner
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745674/ https://www.ncbi.nlm.nih.gov/pubmed/35008581 http://dx.doi.org/10.3390/ijms23010156

Ejemplares similares

Ranking noncanonical 5′ splice site usage by genome-wide RNA-seq analysis and splicing reporter assays
por: Erkelenz, Steffen, et al.
Publicado: (2018)

Succession of splicing regulatory elements determines cryptic 5΄ss functionality
por: Brillen, Anna-Lena, et al.
Publicado: (2017)

Modeling splicing outcome by combining 5′ss strength and splicing regulatory elements
por: Müller, Lisa, et al.
Publicado: (2022)

Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
por: Müller, Lisa, et al.
Publicado: (2022)

Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code
por: Ptok, Johannes, et al.
Publicado: (2021)

Gymnotic Delivery of LNA Mixmers Targeting Viral SREs Induces HIV-1 mRNA Degradation
por: Hillebrand, Frank, et al.
Publicado: (2019)

Validation of Splicing Events in Transcriptome Sequencing Data
por: Kaisers, Wolfgang, et al.
Publicado: (2017)

RT-PCR Testing of Organ Culture Medium for Corneal Storage Fails to Detect SARS-CoV-2 Infection Due to Lack of Viral Replication
por: Müller, Lisa, et al.
Publicado: (2022)

Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts
por: Adams, Ortwin, et al.
Publicado: (2022)

Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting
por: Müller, Lisa, et al.
Publicado: (2021)

VarCon: An R Package for Retrieving Neighboring Nucleotides of an SNV
por: Ptok, Johannes, et al.
Publicado: (2020)

Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations
por: Dröge, Carola, et al.
Publicado: (2016)

SARS-CoV-2 Infection in Fully Vaccinated Individuals of Old Age Strongly Boosts the Humoral Immune Response
por: Müller, Lisa, et al.
Publicado: (2021)

Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
por: Erkelenz, Steffen, et al.
Publicado: (2015)

Exclusion of Exon 2 Is a Common mRNA Splice Variant of Primate Telomerase Reverse Transcriptases
por: Withers, Johanna B., et al.
Publicado: (2012)

The Exon Junction Complex and intron removal prevent re-splicing of mRNA
por: Joseph, Brian, et al.
Publicado: (2021)

Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer
por: Asang, Corinna, et al.
Publicado: (2008)

Phosphorylation of pICln by the autophagy activating kinase ULK1 regulates snRNP biogenesis and splice activity of the cell
por: Esser, Lea Marie, et al.
Publicado: (2023)

Effect of exonic splicing regulation on synonymous codon usage in alternatively spliced exons of Dscam
por: Takahashi, Aya
Publicado: (2009)

The Usage of Exon-Exon Splice Junctions for the Detection of Alternative Splicing using the REIDS model
por: Van Moerbeke, Marijke, et al.
Publicado: (2018)

Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
por: Ke, Shengdong, et al.
Publicado: (2010)

Abnormal Pre-mRNA Splicing in Exonic Fabry Disease-Causing GLA Mutations
por: Alfen, Franziska, et al.
Publicado: (2022)

SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon
por: Ha, Jiyeon, et al.
Publicado: (2021)

Interplay between Exonic Splicing Enhancers, mRNA Processing, and mRNA Surveillance in the Dystrophic Mdx Mouse
por: Buvoli, Massimo, et al.
Publicado: (2007)

Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF
por: Chen, Zhiqi, et al.
Publicado: (2010)

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
por: Szafranski, Karol, et al.
Publicado: (2014)

Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
por: Pillmann, Holger, et al.
Publicado: (2011)

Sample Size Estimation for Detection of Splicing Events in Transcriptome Sequencing Data
por: Kaisers, Wolfgang, et al.
Publicado: (2017)

Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays
por: Cheung, Hannah C, et al.
Publicado: (2008)

SR proteins regulate V(6) exon splicing of CD44 pre-mRNA
por: Loh, Tiing Jen, et al.
Publicado: (2016)

High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells
por: Gonnissen, Stefanie, et al.
Publicado: (2019)

Splicing of designer exons informs a biophysical model for exon definition
por: Arias, Mauricio A., et al.
Publicado: (2015)

CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes
por: Steckelberg, Anna-Lena, et al.
Publicado: (2015)

Loss of Endocan tumorigenic properties after alternative splicing of exon 2
por: Depontieu, Florence, et al.
Publicado: (2008)

Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12
por: Haque, Ariful, et al.
Publicado: (2010)

The U1, U2 and U5 snRNAs crosslink to the 5′ exon during yeast pre-mRNA splicing
por: McGrail, Joanne C., et al.
Publicado: (2008)

3′ Splice Site Sequences of Spinal Muscular Atrophy Related SMN2 Pre-mRNA Include Enhancers for Nearby Exons
por: Cho, Sunghee, et al.
Publicado: (2014)

The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons
por: Koren, Eli, et al.
Publicado: (2007)

Identification of an exonic splicing silencer in exon 6A of the human VEGF gene
por: Wang, Rui, et al.
Publicado: (2009)

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays
por: Kechris, Katerina, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_tqc4jq44e9k09ritum5qt57hn9