Cargando…

Autoantibodies Targeting AT(1)- and ET(A)-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor

Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombotic microangiopathy. Evidence suggests a pathogenic role of immunoglobulin G (IgG) targeting G-protein coupled receptors (GPCR). We therefore dissected...

Descripción completa

Detalles Bibliográficos
Autores principales:	Catar, Rusan, Herse-Naether, Melanie, Zhu, Nan, Wagner, Philine, Wischnewski, Oskar, Kusch, Angelika, Kamhieh-Milz, Julian, Eisenreich, Andreas, Rauch, Ursula, Hegner, Björn, Heidecke, Harald, Kill, Angela, Riemekasten, Gabriela, Kleinau, Gunnar, Scheerer, Patrick, Dragun, Duska, Philippe, Aurelie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745726/ https://www.ncbi.nlm.nih.gov/pubmed/35008670 http://dx.doi.org/10.3390/ijms23010244

Ejemplares similares

Intrinsic Deregulation of Vascular Smooth Muscle and Myofibroblast Differentiation in Mesenchymal Stromal Cells from Patients with Systemic Sclerosis
por: Hegner, Björn, et al.
Publicado: (2016)

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation
por: Philippe, Aurélie, et al.
Publicado: (2022)

17ß-Estradiol Regulates mTORC2 Sensitivity to Rapamycin in Adaptive Cardiac Remodeling
por: Kusch, Angelika, et al.
Publicado: (2015)

Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients
por: Günther, Jeannine, et al.
Publicado: (2014)

IL-17 in Peritoneal Dialysis-Associated Inflammation and Angiogenesis: Conclusions and Perspectives
por: Witowski, Janusz, et al.
Publicado: (2018)

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis
por: Kill, Angela, et al.
Publicado: (2014)

Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells
por: Simon, Michèle, et al.
Publicado: (2021)

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling
por: Moll, Guido, et al.
Publicado: (2023)

Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism
por: Zhao, Hongfan, et al.
Publicado: (2023)

Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting
por: Speck, David, et al.
Publicado: (2022)

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling
por: Catar, Rusan, et al.
Publicado: (2021)

Regulation of Chemokine CCL5 Synthesis in Human Peritoneal Fibroblasts: A Key Role of IFN-γ
por: Kawka, Edyta, et al.
Publicado: (2014)

Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis
por: Weigold, Florian, et al.
Publicado: (2018)

Nailfold Videocapillaroscopy for Non-Invasive Assessment of Microcirculation and Prognostic Correlation with Endothelial Dysfunction, Cardiovascular Risk Factors, and Non-HLA Antibodies in Heart Transplant Recipients: A Pilot Study
por: Sikorska, Dorota, et al.
Publicado: (2023)

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells
por: Sadeghi, Behnam, et al.
Publicado: (2019)

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response
por: Catar, Rusan, et al.
Publicado: (2021)

Native and Oxidized Low-Density Lipoproteins Increase the Expression of the LDL Receptor and the LOX-1 Receptor, Respectively, in Arterial Endothelial Cells
por: Catar, Rusan, et al.
Publicado: (2022)

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS
por: Hartwig, Jelka, et al.
Publicado: (2020)

Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia
por: Kamhieh-Milz, Julian, et al.
Publicado: (2014)

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy
por: Catar, Rusan Ali, et al.
Publicado: (2022)

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice
por: Zhu, Ye, et al.
Publicado: (2016)

Publisher Correction: mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
por: Schaub, Theres, et al.
Publicado: (2020)

mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
por: Schaub, Theres, et al.
Publicado: (2019)

Specific Autoantibodies in Neovascular Age-Related Macular Degeneration: Evaluation of Morphological and Functional Progression over Five Years
por: Prasuhn, Michelle, et al.
Publicado: (2021)

High cut-off dialysis mitigates pro-calcific effects of plasma on vascular progenitor cells
por: Schaub, Theres, et al.
Publicado: (2021)

Predictive and Prognostic Value of sPRR in Patients with Primary Epithelial Ovarian Cancer
por: Kreienbring, Katrin, et al.
Publicado: (2016)

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis
por: Cabral-Marques, Otavio, et al.
Publicado: (2018)

Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3
por: Recke, Andreas, et al.
Publicado: (2018)

The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers
por: Kopetschke, Katharina, et al.
Publicado: (2015)

Cancer Risks Associated with Arsenic: Lamm et al. Respond
por: Lamm, Steven H., et al.
Publicado: (2007)

Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro
por: Hegner, Björn, et al.
Publicado: (2018)

The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease
por: Eder, Piotr, et al.
Publicado: (2019)

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice
por: Klocke, Jan, et al.
Publicado: (2019)

Differentially Expressed MicroRNAs in Maternal Plasma for the Noninvasive Prenatal Diagnosis of Down Syndrome (Trisomy 21)
por: Kamhieh-Milz, Julian, et al.
Publicado: (2014)

What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases
por: Riemekasten, Gabriela, et al.
Publicado: (2020)

Autoantibodies as Biomarker and Therapeutic Target in Systemic Sclerosis
por: Graßhoff, Hanna, et al.
Publicado: (2022)

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
por: Freitag, Helma, et al.
Publicado: (2021)

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties
por: Andrzejewska, Anastazja, et al.
Publicado: (2019)

Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach
por: Fonseca, Dennyson Leandro M., et al.
Publicado: (2023)

Make the grade for Wegener's granulomatosis after kidney transplantation
por: Schewior, Lioba, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_k237kfot49p5cgiflp5e17opo1