Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and with these, the...

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Detalles Bibliográficos
Autores principales: Umemura, Yasuhiro, Koike, Nobuya, Tsuchiya, Yoshiki, Watanabe, Hitomi, Kondoh, Gen, Kageyama, Ryoichiro, Yagita, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746294/
https://www.ncbi.nlm.nih.gov/pubmed/34930826
http://dx.doi.org/10.1073/pnas.2114083119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746294/
https://www.ncbi.nlm.nih.gov/pubmed/34930826
http://dx.doi.org/10.1073/pnas.2114083119

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